3,5-Dimethyl-4-hydroxybenzonitrile → HCID 178426653, compound

HRID 2040809Notes

Reaction equation

HRID 2040809 reaction equation
CC1C=C(C=C(C)C=1O)C#N.[C:12]([O:16][C:17](=[O:33])[CH2:18][CH2:19][C:20]1[C:25]([CH3:26])=[CH:24][C:23]([C:27](=[NH:30])[NH:28][OH:29])=[CH:22][C:21]=1[CH2:31]C)([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17](=[O:33])[CH2:18][CH2:19][C:20]1[C:21]([CH3:31])=[CH:22][C:23]([C:27](=[NH:30])[NH:28][OH:29])=[CH:24][C:25]=1[CH3:26])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 201763,5-Dimethyl-4-hydroxybenzonitrileHCID 178436624tert-butyl 3-[2-ethyl-4-[(Z)-N'-hydroxycarbamimidoyl]-6-methylphenyl]propanoate

Product 1

HCID 178426653HCID 178426653, compound

Procedure

The title compound is prepared starting from 3,5-dimethyl-4-hydroxybenzonitrile following steps b), c), d), and g) of the preparation of 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester; LC-MS: tR=0.75 min, [M+1]+=293.09.

Sources & evidence

ORD record
ord-5d78e6ad6e6c40b086e263c1fa75ae02
Source dataset
uspto-grants-2013_11
Patent number
US08580824B2

Reaction notes

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