HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → (Rs)-4-[3-(3-ethyl-5-methyl-4-oxiranylmethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-isobutyl-6-methyl-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | 2-Ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol | HCID 135923904 | — |
| Product | (Rs)-4-[3-(3-ethyl-5-methyl-4-oxiranylmethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-isobutyl-6-methyl-pyridine | HCID 87495238 | — |
Reaction Steps
In analogy to Example 14, 2-ethyl-4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenol is alkylated with epichlorhydrine to give (RS)-4-[3-(3-ethyl-5-methyl-4-oxiranylmethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-2-isobutyl-6-methyl-pyridine as a colourless oil; LC-MS: tR=1.00 min, [M+1]+=408.18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580824B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d546b8d3b3ce40349f120fdeab077e27 |
| Source note | uspto-grants-2013_11 |