3-Ethyl-4-hydroxy-5-methyl-benzoic acid → 2-Ethyl-4-[3-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol

HRID 2040827Notes

Reaction equation

HRID 2040827 reaction equation
[OH:1][NH:2][C:3](=[NH:15])[C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([CH2:11][CH:12]([CH3:14])[CH3:13])[CH:5]=1.[CH2:16]([C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[C:21](O)=O)[CH3:17]>>[CH2:16]([C:18]1[CH:19]=[C:20]([C:21]2[O:1][N:2]=[C:3]([C:4]3[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([CH2:11][CH:12]([CH3:13])[CH3:14])[CH:5]=3)[N:15]=2)[CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[CH3:17]

Participants

3

Reactant 2

HCID 592347773-Ethyl-4-hydroxy-5-methyl-benzoic acidHCID 178426661HCID 178426661, compound

Product 1

HCID 1359642062-Ethyl-4-[3-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol

Procedure

2-Ethyl-4-[3-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-6-methyl-phenol is prepared from N-hydroxy-2-isobutyl-6-methyl-isonicotinamidine and 3-ethyl-4-hydroxy-5-methyl-benzoic acid; LC-MS: tR=0.90 min, [M+1]+=352.17.

Sources & evidence

ORD record
ord-dfcb16c8a2b44da4a6a1dde429b36682
Source dataset
uspto-grants-2013_11
Patent number
US08580824B2

Reaction notes

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