HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine-3-carboxylic acid hydrochloride → (RS)-1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-pyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine-3-carboxylic acid hydrochloride | HCID 44890816 | — |
| Reactant | {4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid | HCID 59234753 | — |
| Product | (RS)-1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-pyrrolidine-3-carboxylic acid | HCID 59234719 | — |
Reaction Steps
(RS)-1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-pyrrolidine-3-carboxylic acid is prepared from {4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid and (RS)-pyrrolidine-3-carboxylic acid hydrochloride in analogy to Example 65; LC-MS: tR=0.82, [M+1]+=448.10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580824B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-e1e9cb301f034a918d68efeacc8b43b0 |
| Source note | uspto-grants-2013_11 |