HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl azetidine-3-carboxylate → 1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl azetidine-3-carboxylate | HCID 20132751 | — |
| Reactant | {4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid | HCID 59234753 | — |
| Solvent | NaOH dioxane | HCID 18323598 | — |
| Product | 1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid | HCID 59234752 | — |
| Product | 1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid methyl ester | HCID 68555643 | — |
Reaction Steps
1-(2-{4-[5-(2-Isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid methyl ester is prepared from {4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetic acid and azetidine-3-carboxylic acid methyl ester in analogy to Example 65; stirring this material in 3 N aq. NaOH/dioxane at rt for 20 h gives 1-(2-{4-[5-(2-isobutyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-acetyl)-azetidine-3-carboxylic acid; LC-MS: tR=0.80, [M+1]+=435.02.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580824B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-36e69c82e9184889a8b8c7379ede49ec |
| Source note | uspto-grants-2013_11 |