HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-6-methylpyridine → 8-(6-Methyl-3-nitropyridin-2-yl)-3-(pyridin-3-ylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-6-methylpyridine | HCID 79205 | — |
| Reactant | 6-Methyl-2-(4-methylene-1-piperidyl)-3-nitropyridine | HCID 57493810 | — |
| Product | 8-(6-Methyl-3-nitropyridin-2-yl)-3-(pyridin-3-ylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene | HCID 56646064 | — |
Reaction Steps
The title compound was prepared following the procedure reported for the compound of Example 3, replacing 3-iodopyridine for 2-bromo-6-methylpyridine. After the usual work-up, the crude was purified by automated flash chromatography (SP1®TM-Biotage; gradient Petroleum Ether-EtOAc from 7:3 to 3:7) affording the title product as yellow solid. Yield: 66.7%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-68afeca8aad14cf2a455dac120970913 |
| Source note | uspto-grants-2013_11 |