Sodium Carbonate → HCID 86762124, compound

Participants

Reaction Steps

A suspension of 1-(6-methyl-4-methylen-3-nitro-2-pyridyl)piperidine (Compound 3a, 350 mg, 1.5 mmol), sodium carbonate (1.26 g, 15 mmol) and dibromoformaldoxime (608 mg, 3 mmol) in 25 mL of EtOAc was stirred at r.t. for 2 days. Afterwards, the reaction mixture was washed with water, dried over sodium sulphate and evaporated to dryness in vacuo. The crude was purified by automated flash chromatography (SP1®TM-Biotage; gradient Petroleum Ether-EtOAc from 9:1 to 6:4) giving 377 mg of the title product. Yield: 70.8%.

Provenance & Evidence