3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → 3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene

HRID 2040854Notes

Reaction equation

HRID 2040854 reaction equation
C1(C#CC2CC3(CCNCC3)ON=2)C=CC=CC=1.[Cl:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:32][C:31]3([CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1>>[Cl:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:32][C:31]3([CH2:36][CH2:35][NH:34][CH2:33]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493821Tert-butyl 3-[(3-chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxylate

Product 1

HCID 574938223-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene

Procedure

The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 27c. The crude residue was used without further purification in the next reaction.

Workup

  1. customThe crude residue was used without further purification in the next reaction

Sources & evidence

ORD record
ord-6471c7c0e3d441ae8af218aff5175e5e
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

Loading…