3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → 7-[(3-Chlorophenyl)ethynyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-ene

HRID 2040856Notes

Reaction equation

HRID 2040856 reaction equation
C1(C#CC2CC3(CCNCC3)ON=2)C=CC=CC=1.[Cl:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:32][C:31]3(CC[N:34]([C:37](OC(C)(C)C)=O)[CH2:33]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1>>[Cl:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:32][C:31]3([CH2:33][NH:34][CH2:37]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493821Tert-butyl 3-[(3-chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxylate

Product 1

HCID 574938257-[(3-Chlorophenyl)ethynyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-ene

Procedure

The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 27c. The crude residue was used without further purification in the next reaction step.

Workup

  1. customThe crude residue was used without further purification in the next reaction step

Sources & evidence

ORD record
ord-7d03b6f7bcd04a839575bf04df5200d6
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

Loading…