8-Methylidene-1,4-dioxaspiro[4.5]decane → 3-[(3-Chlorophenyl)ethynyl]-8-methylene-1-oxa-2-azaspiro[4.5]dec-2-ene

Participants

Reaction Steps

The title compound was synthesized using the same methodology described for Compound 31a, but starting from the compound of Example 32 instead of 1,4-dioxaspiro[4.5]decan-8-one. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (Horizon®TM-Biotage; gradient Petroleum Ether-Acetone EtOAc from 95:5 to 9:1) to give the title compound as a grey solid. Yield: 67.3%

Provenance & Evidence