HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → 3-[(6-Methylpyridin-2-yl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene | HCID 57493808 | — |
| Reactant | tert-Butyl 3-[(6-methylpyridin-2-yl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxylate | HCID 57493833 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-[(6-Methylpyridin-2-yl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene | HCID 57493834 | 94.5% |
Reaction Steps
The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 35a and running the reaction in chloroform. The crude brownish oily residue was used without further purification in the next reaction step. Yield: 94.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2db1f32d642542758012f1937ce7446e |
| Source note | uspto-grants-2013_11 |