3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → HCID 57493836, compound

HRID 2040866Notes

Reaction equation

HRID 2040866 reaction equation
[C:1]1([C:7]#[C:8][C:9]2[CH2:13][C:12]3([CH2:18][CH2:17][NH:16][CH2:15]C3)[O:11][N:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C#CC2CC3(CCN(C(OC(C)(C)C)=O)C3)ON=2)C=CC=CC=1>C(Cl)(Cl)Cl>[C:1]1([C:7]#[C:8][C:9]2[CH2:13][C:12]3([CH2:18][CH2:17][NH:16][CH2:15]3)[O:11][N:10]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493835HCID 57493835, compound

Product 1

HCID 57493836HCID 57493836, compoundYield 91.3%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 36a and running the reaction in chloroform. The crude brownish oily residue was used without further purification in the next reaction step. Yield: 91.3%.

Workup

  1. customThe crude brownish oily residue was used without further purification in the next reaction step

Sources & evidence

ORD record
ord-a32965e18be9447f87556279047d9f29
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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