3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → HCID 57493838, compound

HRID 2040867Notes

Reaction equation

HRID 2040867 reaction equation
C1(C#CC2CC3(CCNCC3)ON=2)C=CC=CC=1.[F:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:32][C:31]3([CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1>C(Cl)(Cl)Cl>[F:19][C:20]1[CH:21]=[C:22]([C:26]#[C:27][C:28]2[CH2:32][C:31]3([CH2:36][CH2:35][NH:34][CH2:33]3)[O:30][N:29]=2)[CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 574938083-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-eneHCID 57493837HCID 57493837, compound

Product 1

HCID 57493838HCID 57493838, compoundYield 91.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 37a and running the reaction in chloroform. The crude brownish oily residue was used without further purification in the next reaction step. Yield: 91.8%.

Workup

  1. customThe crude brownish oily residue was used without further purification in the next reaction step

Sources & evidence

ORD record
ord-da2087fa252d4fa6ac6cb27b4f0439c5
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

Loading…