HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methyl-2-(4-methylene-1-piperidyl)-3-nitropyridine → 3-[(6-Methylpyridin-2-yl)ethynyl]-8-pyridin-2-yl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methyl-2-(4-methylene-1-piperidyl)-3-nitropyridine | HCID 57493810 | — |
| Reactant | 8-(2-Pyridyl)-2-(2-trimethylsilylethynyl)-4-oxa-3-azaspiro[4.5]dec-2-ene-8-carbonitrile | HCID 57493846 | — |
| Product | 3-[(6-Methylpyridin-2-yl)ethynyl]-8-pyridin-2-yl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile | HCID 56643609 | — |
Reaction Steps
The title compound was prepared following the method described for the compound of Example 3, replacing Compound 3c with Compound 48b. The crude was purified by automated flash chromatography (SP1®TM-Biotage; gradient Petroleum ether-EtOAc from 65:35 to 4:6) to give the title compound as yellow oil. Yield: 43.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-f1a935ea5dab4695a47b79b53d0c3c42 |
| Source note | uspto-grants-2013_11 |