Sodium Hydroxide → HCID 56644224, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the Compound of Example 47 (14 mg, 0.4 mmol) in 1.75 mL of dioxane was added 1M sodium hydroxide (40 μL, 0.4 mmol) and the reaction mixture was stirred at 40° C. for 2 h. After evaporation to dryness, the crude was purified by automated RP flash chromatography (SP1®TM-Biotage; gradient 20 mM aqueous ammonium carbonate-MeCN from 1:0 to 6:4) to give 10 mg of the title compound as a white solid.

Provenance & Evidence