HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → 3-(5-Oxa-2,6-diazaspiro[3.4]oct-6-en-7-ylethynyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene | HCID 57493808 | — |
| Reactant | Tert-butyl 7-[(3-hydroxyphenyl)ethynyl]-5-oxa-2,6-diazaspiro[3,4]oct-6-ene-2-carboxylate | HCID 66603439 | — |
| Product | 3-(5-Oxa-2,6-diazaspiro[3.4]oct-6-en-7-ylethynyl)phenol | HCID 57493851 | 90.4% |
Reaction Steps
The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 80b. The crude residue was used without further purification in the next reaction. Yield: 90.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-5755788d8f87413ea0bc60d8a8253b44 |
| Source note | uspto-grants-2013_11 |