HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene → 3-(5-Oxa-2,6-diazaspiro[3.4]oct-6-en-7-ylethynyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Phenylethynyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene | HCID 57493808 | — |
| Reactant | tert-Butyl 7-[(3-cyanophenyl)ethynyl]-5-oxa-2,6-diazaspiro[3.4]oct-6-ene-2-carboxylate | HCID 57493852 | — |
| Product | 3-(5-Oxa-2,6-diazaspiro[3.4]oct-6-en-7-ylethynyl)benzonitrile | HCID 57493853 | 90.4% |
Reaction Steps
The title compound was synthesized following the method reported for the Compound 1c, substituting Compound 1b with Compound 81a. The crude residue was used without further purification in the next reaction. Yield: 90.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-840080b284ac4c1a97e9c3aaf34e5ba8 |
| Source note | uspto-grants-2013_11 |