HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Methylenespiro[4.5]decane → 3-[(3-Methylphenyl)ethynyl]-1-oxa-2-azadispiro[4.2.4.2]tetradec-2-ene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Methylenespiro[4.5]decane | HCID 57493856 | — |
| Reactant | N-hydroxy-3-(m-tolyl)prop-2-ynimidoyl chloride | HCID 86662877 | — |
| Product | 3-[(3-Methylphenyl)ethynyl]-1-oxa-2-azadispiro[4.2.4.2]tetradec-2-ene | HCID 56644437 | — |
Reaction Steps
The title compound was prepared following the procedure described for Compound 3c, using Compound 91d instead of Compound 3b and Compound 89a instead of Compound 3a. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (ISOLERA®TM-Biotage; gradient Petroleum Ether-EtOAc from 97:3 to 9:1) to give the title compound as a white-yellowish solid. Yield: 55.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6163f8e566004cc097db5b08b8600e4e |
| Source note | uspto-grants-2013_11 |