HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,5-Dioxaspiro[5.5]undecan-9-one → 9-Methylidene-1,5-dioxaspiro[5.5]undecane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,5-Dioxaspiro[5.5]undecan-9-one | HCID 10313300 | — |
| Reactant | tert-Butyl 3-methylideneazetidine-1-carboxylate | HCID 55269097 | — |
| Product | 9-Methylidene-1,5-dioxaspiro[5.5]undecane | HCID 57493860 | — |
Reaction Steps
The title compound was prepared following the methodology described for Compound 28a replacing 1-Boc-3-azetidinone with 7,11-dioxaspiro[5.5]undecan-3-one. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; Et2O) to give the title compound as a pale-yellow oil. Yield: 96.3%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-7ed4c19434d44a6b98126ccf2a6640a8 |
| Source note | uspto-grants-2013_11 |