HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-oxocyclohexanecarboxylate → Ethyl 4-methylidenecyclohexane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-oxocyclohexanecarboxylate | HCID 317638 | — |
| Reactant | 1,4-Dioxaspiro[4.5]decan-8-one | HCID 567415 | — |
| Reactant | 8-Methylidene-1,4-dioxaspiro[4.5]decane | HCID 10953743 | — |
| Product | Ethyl 4-methylidenecyclohexane-1-carboxylate | HCID 15151435 | 68.7% |
Reaction Steps
This intermediate was prepared following the procedure described Compound 31a. As starting material ethyl 4-oxocyclohexane-1-carboxylate replaced 1,4-dioxaspiro[4.5]decan-8-one. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 4:6) to give the title compound as a colorless oil. Yield: 68.7%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-84a98e0dcd7b4e9685320e61e9f9d044 |
| Source note | uspto-grants-2013_11 |