反应详情

To a solution of Compound 27d (150 mg, 0.58 mmol) in dichloromethane (10 mL) was added TEA (0.248 mL, 1.73 mmol) followed by 4-methyl-1-piperazinecarbonyl chloride (122 mg, 0.748 mmol). The reaction mixture was kept under stirring for 20 h. After evaporation the residue was purified by means of automated isocratic RP chromatography (SP01®TM-Biotage; NH4HCO3/AcCN 55:45) affording 91 mg of the title compound as a gummy oil. Yield: 49%.

1. customAfter evaporation the residue
2. customwas purified by means of automated isocratic RP chromatography (SP01®TM-Biotage; NH4HCO3/AcCN 55:45)