HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-1-piperazinecarbonyl chloride → 7-[2-(3-Chlorophenyl)ethynyl]-N-methoxy-N-methyl-9-oxa-3,8-diazaspiro[4.4]non-7-ene-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-1-piperazinecarbonyl chloride | HCID 3016935 | — |
| Reactant | {3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-en-7-yl}(4-methyl piperazin-1-yl)methanone | HCID 56644861 | — |
| Product | 7-[2-(3-Chlorophenyl)ethynyl]-N-methoxy-N-methyl-9-oxa-3,8-diazaspiro[4.4]non-7-ene-3-carboxamide | HCID 57493799 | 54.1% |
Reaction Steps
The title compound was synthesized using the method described for the compound of Example 104, replacing N-methoxy-N-methylcarbamoyl chloride for 4-methyl-1-piperazinecarbonyl chloride. After evaporation, the crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient petroleum ether-EtOAc 8:2 to 4:6) to afford a pale yellow solid. Yield: 54.1%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-dc4d44b787724972919d04150189a013 |
| Source note | uspto-grants-2013_11 |