Isopropylethylamine → HCID 57493800, compound

HRID 2040904Notes

Reaction equation

HRID 2040904 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:18][CH2:17][N:16]([C:19]([N:21](CC)[CH:22]([CH3:24])C)=[O:20])[CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:27]([NH:29][CH:30](C)C)[CH3:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([O:12][N:11]=2)[CH2:18][CH2:17][N:16]([C:19]([NH:21][C:22]2[CH:28]=[CH:27][N:29]=[CH:30][CH:24]=2)=[O:20])[CH2:15]3)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 88318IsopropylethylamineHCID 57493786HCID 57493786, compound

Product 1

HCID 57493800HCID 57493800, compoundYield 16.4%

Procedure

The title compound was synthesized using the method described for the compound of Example 109, replacing 4-aminopyridine for ethylisopropylamine. After the usual work-up procedure evaporation, the crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient EtOAc-MeOH/NH3 from 98:2 to 85:15) to afford a pale yellow solid. Yield: 16.4%.

Workup

  1. customAfter the usual work-up procedure evaporation
  2. customthe crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient EtOAc-MeOH/NH3 from 98:2 to 85:15)
  3. customto afford a pale yellow solid

Sources & evidence

ORD record
ord-2a15d42e85544407bc853df8f5c1a2f1
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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