3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamide → HCID 57493792, compound

HRID 2040906Notes

Reaction equation

HRID 2040906 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:18][CH2:17][N:16]([C:19]([NH2:21])=[O:20])[CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.Cl[C:23]1C=C(C#CC2CC3(CCNC3)ON=2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:18][CH2:17][N:16]([C:19]([NH2:21])=[O:20])[CH2:15][CH2:23]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 566446463-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamideHCID 574938223-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene

Product 1

HCID 57493792HCID 57493792, compound

Procedure

The title compound was synthesized following the method herein described for the compound of Example 96 but replacing Compound 22c for Compound 27d. After the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 93:7) giving the title compound as a white solid. Yield: 76.9%.

Workup

  1. customThe title compound was synthesized
  2. customAfter the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 93:7)

Sources & evidence

ORD record
ord-9b774495ed99430683c1205116cb8980
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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