HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57493801, compound → HCID 56644863, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57493801 | HCID 57493801 | — |
| Reactant | 3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene | HCID 57493822 | — |
| Product | HCID 56644863 | HCID 56644863 | — |
Reaction Steps
The title compound was synthesized following the method herein described for the compound of Example 112 but replacing Compound 22c for Compound 27d. After the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 9:1 to 8:2) giving the title compound as a white solid. Yield: 55.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2e0052970f884b07bac31df9c44a23bd |
| Source note | uspto-grants-2013_11 |