HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(3-Chlorophenyl)ethynyl]-N,N-dimethyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamide → 2-[2-(3-Chlorophenyl)ethynyl]-N,N-dimethyl-4-oxa-3,8-diazaspiro[4.5]dec-2-ene-8-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(3-Chlorophenyl)ethynyl]-N,N-dimethyl-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamide | HCID 56644645 | — |
| Reactant | Tert-butyl 3-[(3-chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxylate | HCID 57493821 | — |
| Product | 2-[2-(3-Chlorophenyl)ethynyl]-N,N-dimethyl-4-oxa-3,8-diazaspiro[4.5]dec-2-ene-8-carboxamide | HCID 56644865 | — |
Reaction Steps
The title compound was synthesized following the method herein described for the compound of Example 95 but replacing Compound 22d for Compound 27c. After the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 3:7 to 0:1) giving pale yellow solid of the title compound. Yield: 66.2%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580962B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-10cf996015d14fa398e38efd4f951484 |
| Source note | uspto-grants-2013_11 |