HCID 57493801, compound → HCID 57493804, compound

HRID 2040916Notes

Reaction equation

HRID 2040916 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:18][CH2:17][N:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.ClC1C=C(C#CC2C[C:36]3(CCNC3)[O:35]N=2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH:18]([O:35][CH3:36])[CH2:17][N:16]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 57493801HCID 57493801, compoundHCID 574938223-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene

Product 1

HCID 57493804HCID 57493804, compound

Procedure

The title compound was synthesized following the method herein described for the compound of Example 112 but replacing Compound 126a for Compound 27d. After the usual work-up procedure the crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 8:2 to 1:1) giving the title compound. Yield: 52.6%.

Workup

  1. customThe title compound was synthesized
  2. customAfter the usual work-up procedure the crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient Petroleum Ether-EtOAc from 8:2 to 1:1)

Sources & evidence

ORD record
ord-4b4b72cf88484335858f7b245155ca00
Source dataset
uspto-grants-2013_11
Patent number
US08580962B2

Reaction notes

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