HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4-fluoroaniline → 5,3'-Difluoro-4'-methylbiphenyl-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4-fluoroaniline | HCID 242873 | — |
| Reactant | 3-Fluoro-4-methylbenzeneboronic acid | HCID 2782674 | — |
| Product | 5,3'-Difluoro-4'-methylbiphenyl-2-ylamine | HCID 68938659 | — |
Reaction Steps
Starting from 4-methyl-3-fluorophenylboronic acid and 2-bromo-4-fluoroaniline and proceeding analogously to Example (III-1), the compound 5,3′-difluoro-4′-methylbiphenyl-2-ylamine with a logP (pH 2.3) of 2.94 is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580971B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-e0204ee39b6b4976af59cc4d91d28991 |
| Source note | uspto-grants-2013_11 |