325465-53-0 → HCID 178506734, compound

HRID 2040941Notes

Reaction equation

HRID 2040941 reaction equation
Br[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[CH2:11][CH3:12].C([Li:17])CCC>>[Li:17][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[CH2:11][CH3:12]

Participants

3

Reactant 2

HCID 3790709325465-53-0HCID 178418339Butyllithium

Product 1

HCID 178506734HCID 178506734, compound

Procedure

comprising contacting 3-bromo-2-ethylbenzofuran with n-butyllithium at a temperature less than −75° C. to form 3-lithio-2-ethylbenzofuran, contacting the 3-lithio-2-ethylbenzofuran at a temperature less than −75° C. with an isopropyl boronate cyclic ester corresponding to the formula:

Workup

  1. customat a temperature less than −75° C.

Sources & evidence

ORD record
ord-40e57b72fc0c42f4a6d82da09a0b445b
Source dataset
uspto-grants-2013_11
Patent number
US08580976B2

Reaction notes

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