Diethyl (3-bromopropyl)phosphonate → Diethyl [3-(3-methyl-7-propylxanthin-1-yl)propyl]phosphonate

HRID 2041Notes

Reaction equation

HRID 2041 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][CH2:12][CH3:13])[C:6]=2[C:5](=[O:14])[NH:4][C:3]1=[O:15].Br[CH2:17][CH2:18][CH2:19][P:20]([O:25][CH2:26][CH3:27])(=[O:24])[O:21][CH2:22][CH3:23]>>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][CH2:12][CH3:13])[C:6]=2[C:5](=[O:14])[N:4]([CH2:17][CH2:18][CH2:19][P:20](=[O:24])([O:25][CH2:26][CH3:27])[O:21][CH2:22][CH3:23])[C:3]1=[O:15]

Participants

3

Reactant 2

HCID 283500Diethyl (3-bromopropyl)phosphonateHCID 33143973-Methyl-7-propylpurine-2,6-dione

Product 1

HCID 22446279Diethyl [3-(3-methyl-7-propylxanthin-1-yl)propyl]phosphonate

Procedure

The title substance was prepared from 0.048 mol of 3-methyl-7-propyl-xanthine and 0.058 mol of diethyl 3-bromopropanephosphonate analogously to Example 23.

Sources & evidence

ORD record
ord-7aefd98413d44b3fac3a2bd4ea211f8d
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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