HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2041034Generated: October 26, 2026
Dimethylformamide → 3-[5-amino-4-(3-iodo-benzoyl)-pyrazol-1-yl]-N-methoxy-4-methyl-benzamide
https://huagongshe.com/reaction/2041034
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 3-[5-Amino-4-(3-iodobenzoyl)-pyrazol-1-yl]-4-methylbenzoic acid | HCID 11155072 | — |
| Product | 3-[5-amino-4-(3-iodo-benzoyl)-pyrazol-1-yl]-N-methoxy-4-methyl-benzamide | HCID 11784820 | — |
Reaction Steps
N,N-Dimethylformamide dimethyl acetal (10 mL) was added to the solution of 3-(3-benzyloxy-phenyl)-3-oxo-propionitrile 3 (2.5 g, 10 mmoL) in DMF (20 mL, dry) and the mixture was stirred at 100° C. for 3 hr. Solvent was removed and the residue was purified by silica gel column chromatography (EtOAc as eluent). Product 2-(3-benzyloxy-benzoyl)-3-dimethylamino-acrylonitrile 4 was obtained as a light yellow solid (2.6 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580838B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-02d81253395a4daf9e1c70cae10e16cc |
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| Source note | uspto-grants-2013_11 |
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