HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylacetylene → HCID 66706523, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylacetylene | HCID 575753 | — |
| Reactant | 1,1-Dimethylethyl 6-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate | HCID 57505879 | — |
| Product | HCID 66706523 | HCID 66706523 | 74% |
Reaction Steps
Use a method similar to the General Procedure 3 to couple 3-tert-butoxycarbonyl-6-trifluoromethanesulfonyloxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine (0.6 g, 1.5 mmol) with 3-phenyl-1-propyne (0.38 mL, 3 mmol). Purify by chromatography on silica gel eluting with hexane/EtOAc (1:0, 40:1 and 20:1) to give 3-tert-butoxycarbonyl-6-(3-phenyl-prop-1-ynyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine as an orange oil (400 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-bda2398fb75c4b8e8eb0a927cbe3f837 |
| Source note | uspto-grants-2013_11 |