HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitromethane → HCID 66692011, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 2-Fluoro-5-methoxybenzaldehyde | HCID 2734872 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 66692011 | HCID 66692011 | 97.4% |
Reaction Steps
Heat 2-fluoro-5-methoxybenzaldehyde (15 g, 97.4 mmol) with nitromethane (32 mL, 584 mmol) and ammonium acetate (30 g, 390 mmol) in acetic acid (136 mL) under reflux for 30 min. Evaporate the solvent and dissolve the residue in ether. Wash the organic fraction with water, saturated aqueous NaHCO3 and evaporate to give the desired intermediate (18.7 g, 97%). GC-MS m/z: 197 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ffb1f75d75994092939b37275cd9e508 |
| Source note | uspto-grants-2013_11 |