HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl Formate → HCID 57656138, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl Formate | HCID 61207 | — |
| Reactant | tert-butyl N-(2-hydroxyethyl)carbamate | HCID 2733206 | — |
| Reactant | HCID 58757109 | HCID 58757109 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 57656138 | HCID 57656138 | — |
Reaction Steps
Use a method similar to the General Procedure 4-3, using 7-chloro-6-hydroxy-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (277 mg, 0.94 mmol) and N-(tert-butoxycarbonyl)ethanolamine (244 mg, 1.51 mmol) to give, after chromatography on silica gel eluting with hexane/EtOAc (1:0 and 3:1), the desired intermediate (392 mg, 95%). MS (ES+) m/z: 337 (M+H-Boc)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c8d86e264d4548f0a9bb9e6b1d96fa71 |
| Source note | uspto-grants-2013_11 |