HCID 57656394, compound → HCID 57656121, compound

Participants

Reaction Steps

Dissolve 7-allyl-6-hydroxy-3-(2,2,2-trifluoroacetyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (1.5 g, 5 mmol) in EtOAc (50 mL) containing 10% Pd/C (1.3 g). Stir at ambient temperature at 1 atm with H2 (balloon) for 30 min. Filter the catalyst and wash with water (100 mL). Extract the resulting filtrate three times with EtOAc, wash the combined organic extracts with brine, dry over MgSO4, filter and concentrate in vacuo to give the desired intermediate as a white solid (1.45 g, 97%). MS (ES+) m/z: 302 (M+H)+.

Provenance & Evidence