HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2041131Generated: November 4, 2026
Trifluoroacetic acid → 2-(Benzyloxy)ethanamine
https://huagongshe.com/reaction/2041131
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 21913792 | HCID 21913792 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Benzyloxy)ethanamine | HCID 533868 | 92% |
Reaction Steps
Dissolve (2-benzyloxyethyl)-carbamic acid tert-butyl ester (15 g) in DCM (50 mL), add trifluoroacetic acid (20 mL) and stir at 0° C. for 3 h. Concentrate and dissolve the residue in a minimal amount of DCM. Purify by chromatography on silica gel eluting sequentially with hexane/EtOAc (4:1 and 1:1), EtOAc and 2M ammonia in methanol to give the title compound (8.3 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580780B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-7f067b33188144d99703f4eebc50c8c7 |
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| Source note | uspto-grants-2013_11 |
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