Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-3-Benzyloxy-2-(tert-butoxycarbonylamino)-propane | HCID 11254115 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | tube1041 | HCID 59977290 | 89% |
Reaction Steps
Dissolve (R)-3-benzyloxy-2-(tert-butoxycarbonylamino)-propane (800 mg, 3 mmol) in DCM (10 mL), add trifluoroacetic acid (5 mL), and stir at 0° C. for 20 min. Evaporate and purify by SCX chromatography to give the title compound as a colorless oil (440 mg, 89%). MS (ES+) m/z: 166 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08580780B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-031aad7227c149aeafd37d4a6007df37 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
