HuagongsheHuagongshe Chemistry Print Report · For research reference only
[4-(1-methyl-1H-imidazol-2-yl)-benzyl]-carbamic acid tert-butyl ester → (4-(1-Methyl-1H-imidazol-2-yl)phenyl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [4-(1-methyl-1H-imidazol-2-yl)-benzyl]-carbamic acid tert-butyl ester | HCID 57656293 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | (4-(1-Methyl-1H-imidazol-2-yl)phenyl)methanamine | HCID 57656174 | 75.4% |
Reaction Steps
Dissolve [4-(1-methyl-1H-imidazol-2-yl)-benzyl]-carbamic acid tert-butyl ester (500 mg, 1.7 mmol) in DCM (20 mL) and trifluoroacetic acid (5 mL). Stir the mixture for 1 h at ambient temperature. Concentrate in vacuo and purify by SCX chromatography to obtain the title compound (240 mg, 74%). MS (ES+) m/z: 188 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ddcaa760e2424fbd905ed036f883137c |
| Source note | uspto-grants-2013_11 |