HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-[4-(Ethylsulfonyl)phenyl]methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(Ethanesulfonyl)benzonitrile | HCID 23060675 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[4-(Ethylsulfonyl)phenyl]methanamine | HCID 17966626 | 43% |
Reaction Steps
Combine 4-ethanesulfonyl-benzonitrile (0.7 g, 3.5 mmol), Raney® 3201 nickel (slurry in water, 0.1 g), 2N ammonia in methanol (20 mL) and hydrogenate at 50 psi for 17 h. Filter the reaction mixture through a pad of Celite® and concentrate in vacuo. Purify by SCX chromatography to obtain the title compound as a yellow oil (0.3 g, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-b51d16079f8640baafb75af2ed144ab6 |
| Source note | uspto-grants-2013_11 |