HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → 4-Bromo-N-cyclohexyl-2-fluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Bromo-2-fluorobenzoyl chloride | HCID 2734026 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-N-cyclohexyl-2-fluorobenzamide | HCID 9071195 | 98.1% |
Reaction Steps
Dissolve 4-bromo-2-fluoro-benzoyl chloride (1 g, 4.21 mmol) in DCM and cool the solution in an ice bath. Add triethylamine (0.87 mL, 6.32 mmol) and cyclohexylamine (502 mg, 5.1 mmol) and stir the mixture at ambient temperature for 2 h. Partition the reaction mixture between brine and DCM. Dry the organic layer over Na2SO4, filter and concentrate in vacuo to give the desired intermediate as a white solid (1.24 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c481262aacb84c81ac8d51d9dc446261 |
| Source note | uspto-grants-2013_11 |