HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → 5-(Aminomethyl)-pyridine-2-carboxylic acid cyclohexylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Lithium 5-(tert-butoxycarbonylamino-methyl)-pyridine-2-carboxylate | HCID 57656023 | — |
| Product | 5-(Aminomethyl)-pyridine-2-carboxylic acid cyclohexylamide | HCID 57656247 | 22% |
Reaction Steps
Use the General Procedure 6-2, using cyclohexylamine (1 mL), lithium 5-(tert-butoxycarbonylamino-methyl)-pyridine-2-carboxylate (1 g, 3.96 mmol) and DIEA (5 mL) as cosolvent, to give the title compound as a white solid (200 mg, 22%). MS (ES+) m/z: 234 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2753b9232b4a4fc8a5e9f485e0bdc8d4 |
| Source note | uspto-grants-2013_11 |