HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(6-Fluoropyridin-2-yl)methanamine--hydrogen chloride (1/2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Fluoropyridine-2-carbonitrile | HCID 14296369 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(6-Fluoropyridin-2-yl)methanamine--hydrogen chloride (1/2) | HCID 51342070 | 73% |
Reaction Steps
Dissolve 2-cyano-6-fluoropyridine (300 mg, 2.46 mmol) in absolute ethanol (12 mL). Add 10% Pd/C (93 mg) and concentrated HCl (0.614 mL, 7.37 mmol). Hydrogenate at 40 psi overnight. Filter through Celite® and concentrate to give the title compound as a solid (356 mg, 73%). MS (ES+) m/z: 127 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-1825c43e1c214f9c8a8d835ab110586a |
| Source note | uspto-grants-2013_11 |