Thionyl Chloride → 4-(Chloromethyl)benzo[d][1,3]dioxole

Beteiligte Stoffe

Reaktionsschritte

Dissolve benzo[1,3]dioxol-4-yl-methanol (1.9 g, 12.5 mmol) in thionyl chloride (3 mL, 41.1 mmol) and reflux the reaction mixture for 1 h. Concentrate in vacuo to obtain the desired intermediate as a yellow oil (1.9 g, 91%) that was used without further purification. GC-MS m/z: 170 (M+).

Herkunft & Nachweise