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Diethyl Ether → Methyl benzo[d]thiazole-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Benzothiazole-6-carboxylic acid | HCID 601670 | — |
| 反応物 | N-Methyl-N'-nitro-N-nitrosoguanidine | HCID 135436526 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl benzo[d]thiazole-6-carboxylate | HCID 595763 | 102% |
反応手順
Add 1-methyl-3-nitro-1-nitrosoguanidine (5.0 g, 33.9 mmol) to a mixture of diethyl ether (20 mL) and 1N aqueous NaOH (20 mL) at ambient temperature. Separate the organic layer and add it slowly to a solution of benzothiazole-6-carboxylic acid (1.0 g, 5.58 mmol) in THF (50 mL) at 0° C. Evaporate the solvent to obtain the desired intermediate as a yellow solid (1.1 g, 100%). MS (ES+) m/z: 194 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08580780B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-aed2e20468654b318ab59720f6f0709a |
| 出典メモ | uspto-grants-2013_11 |