Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluorobenzylamine → HCID 86629647, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluorobenzylamine | HCID 66853 | — |
| 반응물 | 3-(2,2,2-Trifluoroacetyl)-6-trifluoromethanesulfonyloxy-7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 57447749 | — |
| 생성물 | HCID 86629647 | HCID 86629647 | 53% |
반응 단계
Use a method similar to the General Procedure 5-1 to couple 3-(2,2,2-trifluoroacetyl)-6-trifluoromethanesulfonyloxy-7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine (110 mg, 0.24 mmol) and 3-fluorobenzyl amine (90 μL, 0.7 mmol). Purify by chromatography on silica gel eluting with hexane/EtOAc (95:5) followed by SCX chromatography to give 6-(3-fluorobenzylamino)-3-(2,2,2-trifluoroacetyl)-7-trifluoromethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine as a yellow oil (55 mg, 53%). MS (ES+) m/z: 435 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08580780B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-67a875f45bbf4291917ca2a82f57c6a6 |
| 출처 메모 | uspto-grants-2013_11 |