HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → (+/-)-2-(1-Chloroethyl)-6-methylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(6-Methylpyridin-2-yl)ethanol | HCID 353138 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (+/-)-2-(1-Chloroethyl)-6-methylpyridine hydrochloride | HCID 66706611 | 85% |
Reaction Steps
To the crude 2-(1-hydroxyethyl)-6-methylpyridine (1.6 g, 11.7 mmol) in dry DCM (1 5 mL) add with stirring thionyl chloride (2.0 mL, 27 mmol) and continue stirring overnight. Concentrate in vacuo, azeotrope three times with dry chloroform and dry under high vacuum to provide the title compound as a tan solid (1.9 g, 85%). MS (APCI+) m/z 156 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-73c354a2fcf14f059f6bd583ea85b8f1 |
| Source note | uspto-grants-2013_11 |