HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Pyridazin-3-yl)ethan-1-one → 1-(Pyridazin-3-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Pyridazin-3-yl)ethan-1-one | HCID 352755 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Pyridazin-3-yl)ethan-1-ol | HCID 15197511 | 93.5% |
Reaction Steps
To 1-pyridazin-3-yl-ethanone (1.4 g, 11.2 mmol) in methanol (112 mL) add sodium borohydride (0.85 g, 22.5 mmol) at 0° C. and stir for 1 h at ambient temperature. Evaporate the mixture and purify by chromatography on silica gel eluting with EtOAc:hexane (1:1 to 1:0) and methanol:EtOAc (0:1 to 1:9) to obtain the title compound (1.3 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-215d95c37523493fac0679b999dee544 |
| Source note | uspto-grants-2013_11 |