HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (2-Fluoro-4-phenoxyphenyl)-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | 2-(2-Fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran | HCID 57656391 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (2-Fluoro-4-phenoxyphenyl)-methanol | HCID 57656488 | 95% |
Reaction Steps
Mix under nitrogen atmosphere 2-(2-fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran (2.05 g, 6.8 mmol), methanol (60 mL) and p-toluenesulfonic acid monohydrate (260 mg, 1.35 mmol). Stir at ambient temperature for 16h. Dilute with EtOAc. Wash with saturated aqueous NaHCO3. Separate the organic layer, dry over Na2SO4 and concentrate in vacuo to give the desired intermediate (1.41 g, 95%). MS (ES+) m/z: 201 (M−OH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-079a7785ffe544e087f4fd046ee169fa |
| Source note | uspto-grants-2013_11 |