HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Chloromethyl)-6-methylpyridine → HCID 66707020, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Chloromethyl)-6-methylpyridine | HCID 76546 | — |
| Reactant | 3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 57655979 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 66707020 | HCID 66707020 | — |
Reaction Steps
Use a method similar to the Example 387, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-chloromethyl-6-methylpryidine to give, after chromatography on silica gel eluting with hexane/EtOAc (4:1) and deprotection by the General Procedure 1-4, the title compound as a white solid. MS (ES+) m/z: 319 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-dbd3b8bd6e2b4d84a42e7d06b2ef084d |
| Source note | uspto-grants-2013_11 |