HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cycloheptanol → 7-Chloro-6-(4-cycloheptyloxybenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cycloheptanol | HCID 10399 | — |
| Reactant | 6-(4-acetoxybenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine | HCID 57656056 | — |
| Product | 7-Chloro-6-(4-cycloheptyloxybenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride | HCID 66706788 | — |
Reaction Steps
Use a method similar to the Example 423 to react 6-(4-acetoxybenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine with cycloheptanol. Use a method similar to the General Procedure 1-4 to give the title compound as a white solid. MS (ES+) m/z: 416 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580780B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ddcffa639acb48e4b76172fb2b22a8be |
| Source note | uspto-grants-2013_11 |